Anticorps Recombinant de lapin anti-Integrin alpha 6

Integrin alpha 6 Recombinant Antibody for IF/ICC, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241703E3

N° de cat : 84463-2-PBS

Synonymes

ITGA6, 241703E3, CD49 antigen-like family member F, CD49f, Integrin alpha-6

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Galerie de données de validation

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  IF Staining of A431 using 84463-2-RR (same clone as 84463-2-PBS)

  Immunofluorescent analysis of (4% PFA) fixed A431 cells using Integrin alpha 6 antibody (84463-2-RR, Clone: 241703E3 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84463-2-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP01334-1

  Cytometric bead array standard curve of MP01334-1, Integrin alpha-6 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 84463-1-PBS. Detection antibody: 84463-2-PBS. Standard: RP00013. Range: 0.781-100 ng/mL.

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  Affinity and Kinetic Characterization of 84463-2-RR

  Biolayer interferometry (BLl) kinetic assays of 84463-2-RR against Human Integrin alpha 6 were performed. The affinity constant is 13.3 nM.

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Informations sur le produit

84463-2-PBS cible Integrin alpha 6 dans les applications de IF/ICC, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: integrin, alpha 6
• Masse moléculaire calculée: 1073 aa, 119 kDa
• Numéro d’acquisition GenBank: BC136456
• Symbole du gène: Integrin alpha 6
• Identification du gène (NCBI): 3655
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 6 (ITGA6, also known as CD49f or VLA-6) is a 120-kDa single-pass type 1 transmembrane glycoprotein, which combines with the beta 1 subunit (ITGB1, CD29) or beta 4 subunit (ITGB4, CD104) to form heterodimeric laminin receptors (PMID: 1976638; 2351695). Integrin alpha 6 mediates cell-to-cell and cell-to-stroma adhesion. It has also been found in many different stem cell populations and is involved in homing and connecting stem cells to their niches and regulating self-renewal mechanisms in stem cells (PMID: 28494695).

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