Anticorps Recombinant de lapin anti-Integrin beta-8

Integrin beta-8 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241549A12

N° de cat : 84558-1-PBS

Synonymes

ITGB8, integrin, beta 8, Integrin beta 8, 241549A12

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Galerie de données de validation

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  WB analysis using 84558-1-RR (same clone as 84558-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84558-1-RR (Integrin beta-8 antibody) at dilution of 1:4500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84558-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84558-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84558-1-RR against Human Integrin beta-8 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

84558-1-PBS cible Integrin beta-8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Integrin beta-8 Protéine recombinante Ag31161
• Nom complet: integrin, beta 8
• Masse moléculaire calculée: 86 kDa
• Poids moléculaire observé: 95-100 kDa
• Numéro d’acquisition GenBank: NM_002214
• Symbole du gène: Integrin beta 8
• Identification du gène (NCBI): 3696
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-8 (ITGB8), belongs to the integrin beta chain family, contains an N-terminal signal peptide, a large extracellular domain that includes four cysteine-rich repeats, a transmembrane domain, and a C-terminal cytoplasmic domain (PMID: 1918072). Integrin beta-8 associates with integrin alpha-V (ITGAV) to form an αvβ8 heterodimer which has been shown to bind vitronectin, fibronectin, and a latency-associated peptide of TGF-β1/3 (PMID: 27033701). Integrin beta-8 contains multiple potential N-linked glycosylation sites. The observed molecular mass of approximately 95-100 kDa for integrin beta-8 is larger than the predicted 86 kDa, consistent with substantial glycosylation (PMID: 1918072).

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