Anticorps Recombinant de lapin anti-Jagged1/CD339

Jagged1/CD339 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241412A6

N° de cat : 98243-1-PBS

Synonymes

Jagged1, JAG1, Protein jagged-1, HJ1, CD339

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98243-1-RR (same clone as 98243-1-PBS)

  1x10^6 HEK-293T cells or Jagged1/CD339 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human Jagged1 Rabbit Recombinant Antibody (98243-1-RR, Clone:241412A6) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98243-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98243-1-RR (same clone as 98243-1-PBS)

  1x10^6 HEK-293T cells (left) or Jagged1/CD339 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human Jagged1/CD339 Rabbit Recombinant Antibody (98243-1-RR, Clone:241412A6) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98243-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98243-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98243-1-RR against Human Jagged1/CD339 were performed. The affinity constant is 1.57 nM.

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Informations sur le produit

98243-1-PBS cible Jagged1/CD339 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: jagged 1 (Alagille syndrome)
• Masse moléculaire calculée: 1218 aa, 134 kDa
• Numéro d’acquisition GenBank: BC098393
• Symbole du gène: Jagged1
• Identification du gène (NCBI): 182
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Jagged1 (JAG1), also known as CD339, is a type I, membrane-anchored, multi-domain protein and a ligand of the Notch receptor (PMID: 15358557). Jagged1 is composed of a relatively small intracellular domain, a transmembrane domain, and a larger extracellular component containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and a signal peptide (PMID: 15358557; 26548814). It is widely expressed throughout mammalian development, across many tissues and developmental stages (PMID: 26548814). The Jagged1-NOTCH interaction can trigger the Notch signaling and activate transcription factors that play key roles in cell differentiation and morphogenesis.

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