Anticorps Recombinant de lapin anti-KCC2/SLC12A5-Specific

KCC2/SLC12A5-Specific Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243141H8

N° de cat : 85751-1-PBS

Synonymes

KCC2, KCC2/SLC12A5, SLC12A5, Electroneutral potassium-chloride cotransporter 2, hKCC2

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Galerie de données de validation

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  WB analysis using 85751-1-RR (same clone as 85751-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85751-1-RR (KCC2/SLC12A5-Specific antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85751-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85751-1-PBS cible KCC2/SLC12A5-Specific dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, souris

• Réactivité: Humain, porc, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: solute carrier family 12 (potassium-chloride transporter), member 5
• Masse moléculaire calculée: 126 kDa
• Poids moléculaire observé: 130-150 kDa
• Numéro d’acquisition GenBank: NM_020708
• Symbole du gène: KCC2
• Identification du gène (NCBI): 57468
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl- cotransporter that is essential for Cl- homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect 130-150 kDa monomer and ~250 kDa dimer of KKC2 in brain lysate. (PMID: 23401525)

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