Anticorps Polyclonal de lapin anti-KCNA1

KCNA1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18067-1-PBS

Synonymes

AEMK, EA1, HBK1, HUK1, KV1.1

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Galerie de données de validation

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  WB analysis using 18067-1-AP (same clone as 18067-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18067-1-AP (KCNA1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18067-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18067-1-PBS cible KCNA1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KCNA1 Protéine recombinante Ag12699
• Nom complet: potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
• Masse moléculaire calculée: 495 aa, 56 kDa
• Poids moléculaire observé: 86 kDa
• Numéro d’acquisition GenBank: BC101733
• Symbole du gène: KCNA1
• Identification du gène (NCBI): 3736
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Potassium voltage-gated channel subfamily A member 1 (KCNA1, also known as Kv1.1) is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PMID: 19903818; 8845167). KCNA1 expression was reduced in human cancers, and this decrease correlated with an increase in breast cancer aggressiveness (PMID: 23774215). Furthermore, Kv1.1 is expressed in the brain as a mature glycoprotein, which is reported to be 86 kDa (PMID: 16305740).

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