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Anticorps Recombinant de lapin anti-KCNA3

KCNA3 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242588H8

N° de cat : 85049-4-PBS

Synonymes

Kv1.3, HUKIII, HPCN3, HLK3, HGK5

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of U-937 cells using KCNA3 Recombinant antibody (85049-4-RR)

    WB analysis of U-937 using 85049-4-RR (same clone as 85049-4-PBS)

    U-937 cells were subjected to SDS PAGE followed by western blot with 85049-4-RR (KCNA3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85049-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85049-4-RR

    Affinity and Kinetic Characterization of 85049-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85049-4-RR against Human KCNA3 were performed. The affinity constant is below 1 pM.

Informations sur le produit

85049-4-PBS cible KCNA3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène KCNA3 Protéine recombinante Ag5204
Nom complet potassium voltage-gated channel, shaker-related subfamily, member 3
Masse moléculaire calculée 575 aa, 64 kDa
Poids moléculaire observé75 kDa
Numéro d’acquisition GenBankBC035059
Symbole du gène KCNA3
Identification du gène (NCBI) 3738
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Kv1.3 ( also known as KCNA3, MK3, HGK5, HLK3, PCN3, HPCN3) contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, which allows nerve cells to repolarize following an action potential efficiently. It plays an essential role in T cell proliferation and activation. Kv1.3 channels are expressed in various tissues and cell types including the brain, vascular smooth muscle cells, and leucocytes. Malfunction of Kv1.3 can alter the immune response, elicit neurotoxic effects or impact on cancer growth(PMID: 24305723; 24133455).

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