Anticorps Polyclonal de lapin anti-KCNH1

KCNH1 Polyclonal Antibody for WB, IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

N° de cat : 26426-1-PBS

Synonymes

EAG, EAG channel 1, EAG1, Ether-a-go-go potassium channel 1, h eag

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Galerie de données de validation

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  WB analysis using 26426-1-AP (same clone as 26426-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 26426-1-AP (KCNH1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26426-1-PBS in a different storage buffer formulation.

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  IP experiment of rat brain using 26426-1-AP (same clone as 26426-1-PBS)

  IP result of anti-KCNH1 (IP:26426-1-AP, 4ug; Detection:26426-1-AP 1:5000) with rat brain tissue lysate 1720 ug. This data was developed using the same antibody clone with 26426-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse brain using 26426-1-AP (same clone as 26426-1-PBS)

  IP result of anti-KCNH1 (IP:26426-1-AP, 4ug; Detection:26426-1-AP 1:5000) with mouse brain tissue lysate 2120 ug. This data was developed using the same antibody clone with 26426-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 26426-1-AP (same clone as 26426-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26426-1-AP (KCNH1 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26426-1-PBS in a different storage buffer formulation.

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  IHC staining of rat brain using 26426-1-AP (same clone as 26426-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 26426-1-AP (KCNH1 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26426-1-PBS in a different storage buffer formulation.

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  IHC staining of rat brain using 26426-1-AP (same clone as 26426-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 26426-1-AP (KCNH1 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26426-1-PBS in a different storage buffer formulation.

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Informations sur le produit

26426-1-PBS cible KCNH1 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KCNH1 Protéine recombinante Ag16647
• Nom complet: potassium voltage-gated channel, subfamily H (eag-related), member 1
• Masse moléculaire calculée: 989 aa, 111 kDa
• Poids moléculaire observé: 111 kDa
• Numéro d’acquisition GenBank: BC113709
• Symbole du gène: KCNH1
• Identification du gène (NCBI): 3756
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Potassium voltage-gated channel subfamily H member 1 (KCNH1, also known as Kv10.1 and EAG) a member of the EAG (ether-à-go-go) family, which is involved in intracellular signaling, cell proliferation, and tumorigenesis (PMID: 35639255). KCNH1 is mainly expressed in the adult central nervous system. It also plays a role in controlling K+ fux that regulates resting membrane potential in excitable and non-excitable cells and is activated at the onset of myoblast differentiation (PMID: 29333676; 27029528; 9738473).

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