Anticorps Recombinant de lapin anti-KCNIP3

KCNIP3 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251515A1

N° de cat : 86579-1-PBS

Synonymes

A-type potassium channel modulatory protein 3, Calsenilin, DRE-antagonist modulator, Kv channel-interacting protein 3

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Galerie de données de validation

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  WB analysis using 86579-1-RR (same clone as 86579-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86579-1-RR (KCNIP3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86579-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86579-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86579-1-RR against Human KCNIP3 were performed. The affinity constant is 0.903 nM.

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Informations sur le produit

86579-1-PBS cible KCNIP3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: KCNIP3 Protéine recombinante Ag2665
• Nom complet: Kv channel interacting protein 3, calsenilin
• Masse moléculaire calculée: 256 aa, 29 kDa
• Poids moléculaire observé: 29 kDa
• Numéro d’acquisition GenBank: BC012850
• Symbole du gène: KCNIP3
• Identification du gène (NCBI): 30818
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KCNIP3 also known as Calsenilin, CSEN, DREAM, or KCHIP3, is a protein-coding gene located on human chromosome 2q11.1 . It encodes a small calcium-binding protein belonging to the recoverin branch of the EF-hand superfamily. KCNIP3 is an integral subunit of native Kv4 channel complexes, regulating A-type potassium currents in response to intracellular calcium changes, thereby modulating neuronal excitability. KCNIP3 interacts with presenilin 1 (PSEN1) and presenilin 2 (PSEN2), influencing γ-secretase activity and β-amyloid formation, potentially linking it to Alzheimer's disease pathology.

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