Anticorps Polyclonal de lapin anti-KCNJ9

KCNJ9 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31742-1-PBS

Synonymes

G protein-activated inward rectifier potassium channel 3, GIRK 3, GIRK3, GIRK-3, KIR3.3

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Galerie de données de validation

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  WB analysis using 31742-1-AP (same clone as 31742-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31742-1-AP (KCNJ9 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31742-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31742-1-PBS cible KCNJ9 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KCNJ9 Protéine recombinante Ag35873
• Nom complet: potassium inwardly-rectifying channel, subfamily J, member 9
• Poids moléculaire observé: 38-44 kDa
• Numéro d’acquisition GenBank: BC167777
• Symbole du gène: KCNJ9
• Identification du gène (NCBI): 3765
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KCNJ9, also known as GIRK3 (G protein-activated inwardly rectifying potassium channel 3), is a crucial subunit that forms inwardly rectifying potassium channels. These channels are primarily activated by inhibitory G proteins (Gi/o) downstream of various G protein-coupled receptors (GPCRs), such as those for neurotransmitters like GABA, acetylcholine, and adenosine. Upon activation, KCNJ9 facilitates potassium efflux, leading to membrane hyperpolarization and a reduction in neuronal excitability. It is widely expressed in the brain, where it plays a key role in regulating synaptic transmission and neuronal circuits, influencing processes ranging from pain perception to reward and motivation.

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