Anticorps Monoclonal anti-KCNN4

KCNN4 Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat, souris

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(6)

CloneNo.

2A6G5

N° de cat : 60276-1-Ig

Synonymes

hIKCa1, hKCa4, hSK4, IK1, IKCA1, KCa3.1, KCA4, KCNN4, Putative Gardos channel, SK4, SKCa 4, SKCa4

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Galerie de données de validation

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  WB analysis of human blood using 60276-1-Ig

  human blood were subjected to SDS PAGE followed by western blot with 60276-1-Ig (KCNN4 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu sanguin humain

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 5 publications below
• IF: See 2 publications below

Informations sur le produit

60276-1-Ig cible KCNN4 dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: KCNN4 Protéine recombinante Ag19774
• Nom complet: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
• Masse moléculaire calculée: 427 aa, 48 kDa
• Poids moléculaire observé: 48 kDa
• Numéro d’acquisition GenBank: BC015337
• Symbole du gène: KCNN4
• Identification du gène (NCBI): 3783
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

The intermediate conductance calcium-activated potassium channel KCNN4, also known as KCa3.1, IK1, or SK4, is a member of the potassium channel KCNN family. KCNN4 is expressed in T cells, mast cells, macrophages, erythrocytes, vascular smooth muscle cells, airway smooth muscle cells, intestinal and airway epithelial cells (PMID: 19681865; 21493782). Functionally, KCNN4 plays a key role in calcium-dependent cell functions, such as proliferation, activation, and migration, in a broad range of cell types (PMID: 21493782).

Publications

Species	Application	Title
mouse	WB	J Inflamm Res; KCa3.1 Inhibition of Macrophages Suppresses Inflammatory Response Leading to Endothelial Damage in a Cell Model of Kawasaki Disease.; Authors - Fenglei Zheng
mouse	WB,IF	Mol Med Rep; M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway; Authors - Huiyu Chen
rat	WB	Acta Cardiol Sin; PMID: 29167619; Authors - Peng Dong
human	WB	Nat Commun; Phospholipid scrambling induced by an ion channel/metabolite transporter complex; Authors - Han Niu
human	WB	J Hematol Oncol; The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA; Authors - Zengyu Feng
mouse	IF	Cell Death Dis; IKCa channels control breast cancer metabolism including AMPK-driven autophagy; Authors - Dominic Gross

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