Anticorps Polyclonal de lapin anti-KCTD7

KCTD7 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32488-1-PBS

Synonymes

BTB/POZ domain-containing protein KCTD7

---

Galerie de données de validation

• 

  WB analysis using 32488-1-AP (same clone as 32488-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32488-1-AP (KCTD7 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32488-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

32488-1-PBS cible KCTD7 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KCTD7 Protéine recombinante Ag35756
• Nom complet: potassium channel tetramerisation domain containing 7
• Masse moléculaire calculée: 33 kDa，289 aa
• Poids moléculaire observé: 62 kDa
• Numéro d’acquisition GenBank: NM_153033.4
• Symbole du gène: KCTD7
• Identification du gène (NCBI): 154881
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KCTD7, or Potassium Channel Tetramerization Domain Containing 7, is a member of the KCTD family of proteins. The role of KCTD7 in regulating autophagy-lysosome pathways, which are essential for cellular homeostasis and response to nutrient stress (PMID: 36964131). It has been implicated in several neurodegenerative disorders, particularly progressive myoclonic epilepsy (PME) and neuronal ceroid lipofuscinosis (NCL). The deficiency of KCTD7 results in the accumulation of lipofuscin and lipid droplets, which are hallmarks of NCL (PMID: 33970744). The 62 kDa form most likely corresponds to an SDS-stable dimer (PMID: 22748208).

{{ptg:RelatedPrimaryAntibodies}}