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Anticorps Polyclonal de lapin anti-KEAP1

KEAP1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30041-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using KEAP1 Polyclonal antibody (30041-1-AP)

    WB analysis using 30041-1-AP (same clone as 30041-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30041-1-AP (KEAP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30041-1-PBS in a different storage buffer formulation.

Informations sur le produit

30041-1-PBS cible KEAP1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène KEAP1 Protéine recombinante Ag32512
Nom complet kelch-like ECH-associated protein 1
Masse moléculaire calculée 624 aa, 70 kDa
Poids moléculaire observé55-70 kDa
Numéro d’acquisition GenBankBC002930
Symbole du gène KEAP1
Identification du gène (NCBI) 9817
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2[PMID: 20173742]. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences[PMID: 22215675]. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1[PMID: 20427290]. It also retains BPTF in the cytosol. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human KEAP1.

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