Anticorps Recombinant de lapin anti-KIF14

KIF14 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243005B8

N° de cat : 85707-1-PBS

Synonymes

Kinesin-like protein KIF14

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Galerie de données de validation

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  WB analysis using 85707-1-RR (same clone as 85707-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85707-1-RR (KIF14 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85707-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85707-1-PBS cible KIF14 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: KIF14 Protéine recombinante Ag23219
• Nom complet: kinesin family member 14
• Poids moléculaire observé: 186 kDa
• Numéro d’acquisition GenBank: BC113742
• Symbole du gène: KIF14
• Identification du gène (NCBI): 9928
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KIF14 (Kinesin Family Member 14) is a microtubule-based motor protein belonging to the kinesin-3 family. It plays essential roles during cell division and has been implicated in various biological processes, including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. KIF14 is highly conserved across species and is characterized by a catalytic motor domain that binds to microtubules and ATP, enabling it to convert chemical energy into mechanical work. KIF14 interacts with the Skp1/Cul1/F-box (SCF) complex, particularly Skp2 and Cks1, to regulate the ubiquitination and degradation of p27Kip1. Knockdown of KIF14 results in the accumulation of p27Kip1, leading to cell cycle arrest and apoptosis.(PMID: 34131133, PMID: 24854087)

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