Anticorps Polyclonal de lapin anti-KIF18B

KIF18B Polyclonal Antibody for IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33139-1-PBS

Synonymes

Kinesin-like protein KIF18B

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Galerie de données de validation

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  IP experiment of Jurkat using 33139-1-AP (same clone as 33139-1-PBS)

  IP result of anti-KIF18B (IP:33139-1-AP, 4ug; Detection:33139-1-AP 1:400) with Jurkat cells lysate 1360 ug. This data was developed using the same antibody clone with 33139-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33139-1-PBS cible KIF18B dans les applications de IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KIF18B Protéine recombinante Ag36663
• Nom complet: kinesin family member 18B
• Masse moléculaire calculée: 852 aa, 93 kDa/833 aa, 91 kDa
• Poids moléculaire observé: 100 kDa
• Numéro d’acquisition GenBank: BC136590
• Symbole du gène: KIF18B
• Identification du gène (NCBI): 146909
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KIF18B is a key member of the kinesin-8 family, involved in regulating various physiological processes such as microtubule length, spindle assembly, and chromosome alignment. This article briefly introduces the structure and physiological functions of KIF18B, examines its role in malignant tumors, and the associated carcinogenic signaling pathways such as PI3K/AKT, Wnt/β-catenin, and mTOR pathways. Research indicates that the upregulation of KIF18B enhances tumor malignancy and resistance to radiotherapy and chemotherapy. KIF18B could become a new target for anticancer drugs, offering significant potential for the treatment of malignant tumors and reducing chemotherapy resistance (PMID: 39259333).

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