Anticorps Recombinant de lapin anti-KIM-1/HAVCR1

KIM-1/HAVCR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242001E8

N° de cat : 98238-1-RR

Synonymes

HAVCR1, KIM-1, TIM-1, KIM1, HAVcr-1

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Galerie de données de validation

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  FC experiment of HuH-7 using 98238-1-RR

  1x10^6 HuH-7 cells (left) or 293-T cells (right) were surface stained with 0.25 ug Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibody (98238-1-RR, Clone: 242001E8) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98238-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98238-1-RR against Human KIM-1/HAVCR1 were performed. The affinity constant is 0.366 nM.

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Applications testées

• Résultats positifs en cytométrie: cellules HuH-7,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98238-1-RR cible KIM-1/HAVCR1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: hepatitis A virus cellular receptor 1
• Masse moléculaire calculée: 39kDa
• Numéro d’acquisition GenBank: NM_001173393.3
• Symbole du gène: HAVCR1
• Identification du gène (NCBI): 26762
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Kidney injury molecule 1 (KIM-1), also known as Hepatitis A virus cellular receptor 1 (HAVCR1), CD365, or T-cell immunoglobulin and mucin domain 1 (TIM-1), is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. KIM-1 acts as a membrane receptor for hepatitis A virus (HAV) (PMID: 9658108; 8861957). KIM-1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). KIM-1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that KIM-1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).

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