Anticorps Recombinant de lapin anti-KIR2DL1

KIR2DL1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242070D11

N° de cat : 85168-1-PBS

Synonymes

242070D11, CD158 antigen-like family member A, CD158a, Killer cell immunoglobulin-like receptor 2DL1, Natural killer-associated transcript 1

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Galerie de données de validation

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  WB analysis using 85168-1-RR (same clone as 85168-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85168-1-RR (KIR2DL1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85168-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 85168-1-RR

  Biolayer interferometry (BLl) kinetic assays of 85168-1-RR against Human KIR2DL1 were performed. The affinity constant is 37.9 nM.

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Informations sur le produit

85168-1-PBS cible KIR2DL1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
• Masse moléculaire calculée: 39 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC069344
• Symbole du gène: KIR2DL1
• Identification du gène (NCBI): 3802
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1, also known as CD158A and NKAT1) is an inhibitory receptor of NK cells, with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling (PMID: 18604210). The effector function of NK cells expressing KIR2DL1 or KIR2DS1 is highly influenced by genetic variability and is calibrated by co-expression of additional NK receptors and cognate HLA-C2 ligands (PMID: 31024561).

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