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Anticorps Polyclonal de lapin anti-KIR2DL3

KIR2DL3 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18966-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of human liver tissue using KIR2DL3 Polyclonal antibody (18966-1-AP)

    WB analysis of human liver using 18966-1-AP (same clone as 18966-1-PBS)

    human liver tissue were subjected to SDS PAGE followed by western blot with 18966-1-AP (KIR2DL3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18966-1-PBS in a different storage buffer formulation.

Informations sur le produit

18966-1-PBS cible KIR2DL3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène KIR2DL3 Protéine recombinante Ag5163
Nom complet killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Masse moléculaire calculée 341 aa, 38 kDa
Poids moléculaire observé 58 kDa
Numéro d’acquisition GenBankBC032422
Symbole du gène KIR2DL3
Identification du gène (NCBI) 3804
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).

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