Anticorps Recombinant de lapin anti-KIR2DL3/CD158b2

KIR2DL3/CD158b2 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242282E11

N° de cat : 98373-3-PBS

Synonymes

KIR2DL3, Killer cell immunoglobulin-like receptor 2DL3, GL183, CD158B2, CD158b

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Galerie de données de validation

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  FC experiment of human PBMCs using 98373-3-RR (same clone as 98373-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human KIR2DL3/CD158b2 Rabbit RecAb (98373-3-RR, Clone: 242282E11) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98373-3-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98373-3-RR (same clone as 98373-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human KIR2DL3/CD158b2 Rabbit RecAb (98373-3-RR, Clone: 242282E11) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98373-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98373-3-PBS cible KIR2DL3/CD158b2 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
• Masse moléculaire calculée: 38 kDa
• Numéro d’acquisition GenBank: NM_015868.2
• Symbole du gène: KIR2DL3
• Identification du gène (NCBI): 3804
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).

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