Anticorps Monoclonal anti-KLF6

KLF6 Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

2F8B3

N° de cat : 67297-1-PBS

Synonymes

BCD1, B-cell-derived protein 1, COPEB, Core promoter element-binding protein, CPBP

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Galerie de données de validation

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  WB analysis using 67297-1-Ig (same clone as 67297-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67297-1-Ig (KLF6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67297-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67297-1-PBS cible KLF6 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: KLF6 Protéine recombinante Ag6859
• Nom complet: Kruppel-like factor 6
• Masse moléculaire calculée: 32 kDa
• Poids moléculaire observé: 32-42 kDa
• Numéro d’acquisition GenBank: BC000311
• Symbole du gène: KLF6
• Identification du gène (NCBI): 1316
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KLF6(krupple-like factor 6) is a zinc finger transcription factor and tumor suppressor with biological activities and transcriptional targets in growing range. It is highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. One key target gene of KLF6 in endoglin, which is a homodimeric cell membrane glycoprotein and TGF-β auxiliary receptor, owns a pro-angiogenic role in endothelial cells and is also involved in malignant progression. Also KLF6 induces apoptosis in prostate cancer cells through upregulation of ATF3. KLF6 was normal detected as a 46kDa protein, which is larger than translation product(32kDa), because of post-translational modification including both phosphorylation and glycosylation. This antibody raise against the full length of KLF6 gene of human origin, and can recognize both of KLF6, included KLF6(~32kDa), p-KLF6(~35-46kDa). Otherwise, there may be a non-specific band(50kDa) showed in detection

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