Anticorps Polyclonal de lapin anti-KLHL7

KLHL7 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 32697-1-AP

Synonymes

Kelch-like protein 7

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Galerie de données de validation

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  WB analysis using 32697-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32697-1-AP (KLHL7 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 32697-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32697-1-AP (KLHL7 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris, cellules HeLa, cellules HepG2, tissu cérébral de rat, tissu de cervelet de rat, tissu de cervelet de souris, tissu testiculaire de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

32697-1-AP cible KLHL7 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KLHL7 Protéine recombinante Ag38050
• Nom complet: kelch-like 7 (Drosophila)
• Masse moléculaire calculée: 586 aa, 66 kDa
• Poids moléculaire observé: 65 kDa
• Numéro d’acquisition GenBank: BC039585
• Symbole du gène: KLHL7
• Identification du gène (NCBI): 55975
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

KLHL7 (Kelch-like protein 7) is a member of the Kelch-like protein family and plays significant roles in various biological processes, including cell cycle regulation, protein degradation, and cytoskeleton organization. KLHL7 is highly expressed in various cancers and is associated with malignant progression and poor prognosis. In breast cancer, high expression of KLHL7 is linked to higher histological grades, estrogen receptor (ER)-negative or human epidermal growth factor receptor 2 (HER-2)-positive tumors, and triple-negative breast cancer (TNBC), and patients with high KLHL7 expression have shorter survival times. In gastric cancer, silencing KLHL7 gene expression can inhibit the proliferation, migration, and invasion of gastric cancer cells and has shown tumor-suppressive effects in in vivo models. Moreover, KLHL7 is highly expressed in colorectal cancer and ovarian cancer, among others, and is significantly associated with low patient survival rates.

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