Anticorps Recombinant de lapin anti-KLRB1/CD161

KLRB1/CD161 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241840F3

N° de cat : 98249-1-PBS

Synonymes

Klrb1a, Killer cell lectin-like receptor subfamily B member 1A, CD161a, CD161 antigen-like family member A, Antigen 3.2.3

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Galerie de données de validation

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  FC experiment of rat splenocytes using 98249-1-RR (same clone as 98249-1-PBS)

  1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody (98249-1-RR, Clone: 241840F3) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98249-1-PBS in a different storage buffer formulation.

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  FC experiment of rat splenocytes using 98249-1-RR (same clone as 98249-1-PBS)

  1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat KLRB1/CD161 Rabbit Recombinant Antibody (98249-1-RR, Clone:241840F3)(red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98249-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98249-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98249-1-RR against Rat KLRB1/CD161 were performed. The affinity constant is 88.8 pM.

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Informations sur le produit

98249-1-PBS cible KLRB1/CD161 dans les applications de FC et montre une réactivité avec des échantillons rat

• Réactivité: rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: killer cell lectin-like receptor subfamily B, member 1A
• Masse moléculaire calculée: 25 kDa
• Numéro d’acquisition GenBank: NM_001010964.1
• Symbole du gène: Klrb1a
• Identification du gène (NCBI): 362443
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).

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