Anticorps Recombinant de lapin anti-KLRB1/CD161

KLRB1/CD161 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

FITC Plus Fluorescent Dye

CloneNo.

242140H5

N° de cat : FITC-98281

Synonymes

CD161, 242140H5, CLEC5B, C-type lectin domain family 5 member B, hNKR P1A

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Galerie de données de validation

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  FC experiment of human peripheral blood leukocytes using FITC-98281

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul FITC Plus Anti-Human KLRB1/CD161 Rabbit RecAb (FITC-98281, Clone: 242140H5) or FITC Plus Rabbit IgG Isotype Control RecAb (FITC-98136, Clone: 240953C9). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: human peripheral blood leukocytes

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

FITC-98281 cible KLRB1/CD161 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: KLRB1/CD161 Protéine recombinante Eg1788
• Nom complet: killer cell lectin-like receptor subfamily B, member 1
• Masse moléculaire calculée: 25 kDa
• Numéro d’acquisition GenBank: NM_002258.3
• Symbole du gène: CD161
• Identification du gène (NCBI): 3820
• Conjugaison: FITC Plus Fluorescent Dye
• Excitation/Emission maxima wavelengths: 495 nm / 524 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).

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