Anticorps Recombinant de lapin anti-KLRG1

KLRG1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242327B12

N° de cat : 84785-4-PBS

Synonymes

MAFA, Killer cell lectin-like receptor subfamily G member 1, ITIM-containing receptor MAFA-L, C-type lectin domain family 15 member A, CLEC15A

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Galerie de données de validation

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  WB analysis using 84785-4-RR (same clone as 84785-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84785-4-RR (KLRG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84785-4-PBS in a different storage buffer formulation.

• 

  WB analysis using 84785-4-RR (same clone as 84785-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84785-4-RR (KLRG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84785-4-PBS in a different storage buffer formulation.

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Informations sur le produit

84785-4-PBS cible KLRG1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: killer cell lectin-like receptor subfamily G, member 1
• Masse moléculaire calculée: 22 kDa
• Poids moléculaire observé: 30-38 kDa
• Numéro d’acquisition GenBank: NM_005810.4
• Symbole du gène: KLRG1
• Identification du gène (NCBI): 10219
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KLRG1 (killer cell lectin-like receptor subfamily G, member 1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is expressed by subsets of NK and T cells, existing both as a monomer and as a disulfide-linked homodimer (PMID: 10741410; 19604491). It is considered to be a cell differentiation marker for NK and T cells and is strongly induced by viral and other infections (PMID: 20373518). Through interactions with members of the cadherin family, KLRG1 plays an inhibitory role in NK- and T-cell function (PMID: 19009530; 20373518). Because of the glycosylation and disulfide bonds of the KLRG1 proteins, the observed molecular weights are typically 30-38 kDa (PMID: 17404256).

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