Anticorps Polyclonal de lapin anti-KMT2C

KMT2C Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28437-1-PBS

Synonymes

MLL3, Lysine N methyltransferase 2C, KIAA1506, Homologous to ALR protein, HALR

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Galerie de données de validation

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  WB analysis using 28437-1-AP (same clone as 28437-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 28437-1-AP (KMT2C antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28437-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary cancer using 28437-1-AP (same clone as 28437-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 28437-1-AP (KMT2C antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28437-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary cancer using 28437-1-AP (same clone as 28437-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 28437-1-AP (KMT2C antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 28437-1-PBS in a different storage buffer formulation.

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Informations sur le produit

28437-1-PBS cible KMT2C dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: KMT2C Protéine recombinante Ag28875
• Nom complet: myeloid/lymphoid or mixed-lineage leukemia 3
• Masse moléculaire calculée: 541 kDa
• Poids moléculaire observé: 541kDa, 269 kDa
• Numéro d’acquisition GenBank: NM_170606
• Symbole du gène: KMT2C
• Identification du gène (NCBI): 58508
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Lysine (K)-specific methyltransferase 2C (KMT2C, also known as MLL3) belongs to the mixed-lineage leukemia (MLL) family of histone methyltransferases which methylate the histone 3 tail at lysine 4 (H3K4) as part of the complex proteins associated with Set 1 (COMPASS) complex. Although originally identified as oncogenic fusions in leukemia, genome-wide mutation studies have revealed frequent, presumably loss-of-function, mutations in various members of the MLL family, including MLL2/KMT2B, MLL3/KMT2C, and MLL4/KMT2D in a variety of malignancies, particularly solid tumors. Mechanistic studies of KMT2C in normal cells have focused primarily on its role in enhancer regulation by deposition of H3K4me1 marks.

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