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Anticorps Polyclonal de lapin anti-Kir2.1

Kir2.1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 19965-1-PBS

Synonymes

KCNJ2, IRK-1, IRK1, IRK 1, hIRK1

Galerie de données de validation

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  • Western Blot (WB) analysis of A549 cells using Kir2.1 Polyclonal antibody (19965-1-AP)

    WB analysis of A549 using 19965-1-AP (same clone as 19965-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 19965-1-AP (Kir2.1 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19965-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A549 cells using Kir2.1 Polyclonal antibody (19965-1-AP)

    WB analysis of A549 using 19965-1-AP (same clone as 19965-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 19965-1-AP (Kir2.1 antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19965-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human brain tissue using Kir2.1 Polyclonal antibody (19965-1-AP)

    IHC staining of human brain using 19965-1-AP (same clone as 19965-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 19965-1-AP (Kir2.1 antibody at dilution of 1:50. This data was developed using the same antibody clone with 19965-1-PBS in a different storage buffer formulation.

Informations sur le produit

19965-1-PBS cible Kir2.1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet potassium inwardly-rectifying channel, subfamily J, member 2
Masse moléculaire calculée 48 kDa
Poids moléculaire observé 50 kDa, 60 kDa
Numéro d’acquisition GenBankNM_000891
Symbole du gène Kir2.1
Identification du gène (NCBI) 3759
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

KCNJ2, also named as HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7 and SQT3, belongs to the inward rectifier-type potassium channel family. KCNJ2 probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ2 can be blocked by extracellular barium or cesium. Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7). Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). The antibody recognizes the C-term of KCNJ2.

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