Anticorps Monoclonal anti-L1CAM/CD171

L1CAM/CD171 Monoclonal Antibody for IF-P

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, porc, rat, souris

Applications

IF-P

Conjugaison

CoraLite® Plus 488 Fluorescent Dye

Publications(1)

CloneNo.

3H7B9

N° de cat : CL488-67115

Synonymes

L1CAM, 3H7B9, CAML1, CD171, HSAS

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Galerie de données de validation

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  IF Staining of mouse brain using CL488-67115

  Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CoraLite® Plus 488 L1CAM antibody (CL488-67115, Clone: 3H7B9 ) at dilution of 1:200.

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  IF Staining of mouse brain using CL488-67115

  Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using CoraLite® Plus 488 L1CAM antibody (CL488-67115, Clone: 3H7B9 ) at dilution of 1:200.

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Applications testées

• Résultats positifs en IF-P: tissu cérébral de souris,

Dilution recommandée

• Immunofluorescence (IF)-P: IF-P : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below

Informations sur le produit

CL488-67115 cible L1CAM/CD171 dans les applications de IF-P et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Réactivité citée: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: L1CAM/CD171 Protéine recombinante Ag17706
• Nom complet: L1 cell adhesion molecule
• Masse moléculaire calculée: 1257 aa, 140 kDa
• Poids moléculaire observé: 220 kDa
• Numéro d’acquisition GenBank: BC126229
• Symbole du gène: L1CAM
• Identification du gène (NCBI): 3897
• Conjugaison: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 493 nm / 522 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Conditions de stockage: Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

L1CAM, also known as NCAM-L1 or CD171, is a cell adhesion molecule of the immunoglobulin superfamily. It is a 200-220 kDa transmembrane glycoprotein composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail (PMID: 3412448; 22796939). L1CAM is primarily expressed in the nervous system and is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts (PMID: 3412448; 10767310). L1CAM is overexpressed in many human cancers and is often associated with bad prognosis (PMID: 27267927; 26111503).

Publications

Species	Application	Title
human	IF	J Extracell Vesicles; Isolation and quantification of L1CAM-positive extracellular vesicles on a chip as a potential biomarker for Parkinson's Disease; Authors - Danyu Li

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