Anticorps Recombinant de lapin anti-L1CAM/CD171

L1CAM/CD171 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240978A7

N° de cat : 98130-1-PBS

Synonymes

L1CAM, 240978A7, CAML1, CD171, HSAS

---

Galerie de données de validation

• 

  FC experiment of SK-N-SH using 98130-1-RR (same clone as 98130-1-PBS)

  1x10^6 SK-N-SH cells were surface stained with 0.25 ug Anti-Human L1CAM/CD171 Rabbit Recombinant Antibody (98130-1-RR, Clone:240978A7) or 0.25 ug Isotype Control, and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98130-1-PBS in a different storage buffer formulation.

• 

  FC experiment of SK-N-SH using 98130-1-RR (same clone as 98130-1-PBS)

  1x10^6 SK-N-SH cells were surface stained with 0.25 ug Anti-Human L1CAM/CD171 Rabbit Recombinant Antibody (98130-1-RR, Clone: 240978A7) (red) or Isotype Control (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98130-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98130-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98130-1-RR against Human L1CAM/CD171 were performed. The affinity constant is 0.243 nM.

---

Informations sur le produit

98130-1-PBS cible L1CAM/CD171 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: L1CAM/CD171 Protéine recombinante Eg0209
• Nom complet: L1 cell adhesion molecule
• Masse moléculaire calculée: 1257 aa, 140 kDa
• Numéro d’acquisition GenBank: BC126229
• Symbole du gène: L1CAM
• Identification du gène (NCBI): 3897
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

L1CAM, also known as NCAM-L1 or CD171, is a cell adhesion molecule of the immunoglobulin superfamily. It is a 200-220 kDa transmembrane glycoprotein composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail (PMID: 3412448; 22796939). L1CAM is primarily expressed in the nervous system and is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts (PMID: 3412448; 10767310). L1CAM is overexpressed in many human cancers and is often associated with bad prognosis (PMID: 27267927; 26111503).

{{ptg:RelatedPrimaryAntibodies}}