Anticorps Recombinant de lapin anti-LAG-3/CD223

LAG-3/CD223 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243086D9

N° de cat : 80855-7-PBS

Synonymes

CD223, LAG3, FDC, LAG 3, LAG-3

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Galerie de données de validation

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  WB analysis of HuT 78 using 80855-7-RR (same clone as 80855-7-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 80855-7-RR (LAG3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80855-7-PBS in a different storage buffer formulation.

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Informations sur le produit

80855-7-PBS cible LAG-3/CD223 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LAG-3/CD223 Protéine recombinante Eg31550
• Nom complet: lymphocyte-activation gene 3
• Masse moléculaire calculée: 57 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: NM_002286
• Symbole du gène: LAG-3
• Identification du gène (NCBI): 3902
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)

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