Anticorps Recombinant de lapin anti-LAIR1

LAIR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242226E10

N° de cat : 98286-1-PBS

Synonymes

mLAIR1, Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305, 242226E10

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98286-1-RR (same clone as 98286-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.13 ug Anti-Mouse LAIR1 Rabbit RecAb (98286-1-RR, Clone:242226E10) or 0.13 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98286-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98286-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98286-1-RR against Mouse LAIR1 were performed. The affinity constant is 0.739 nM.

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Informations sur le produit

98286-1-PBS cible LAIR1 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: leukocyte-associated Ig-like receptor 1
• Masse moléculaire calculée: 30kDa
• Numéro d’acquisition GenBank: NM_001113474.1
• Symbole du gène: Lair1
• Identification du gène (NCBI): 52855
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

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