Anticorps Recombinant de lapin anti-LAIR1

LAIR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242226E10

N° de cat : 98286-1-RR

Synonymes

mLAIR1, Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, CD305, 242226E10

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98286-1-RR

  1x10^6 mouse splenocytes were surface stained with 0.13 ug Anti-Mouse LAIR1 Rabbit RecAb (98286-1-RR, Clone:242226E10) or 0.13 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98286-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98286-1-RR against Mouse LAIR1 were performed. The affinity constant is 0.739 nM.

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Applications testées

• Résultats positifs en cytométrie: splénocytes de souris,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98286-1-RR cible LAIR1 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: leukocyte-associated Ig-like receptor 1
• Masse moléculaire calculée: 30kDa
• Numéro d’acquisition GenBank: NM_001113474.1
• Symbole du gène: Lair1
• Identification du gène (NCBI): 52855
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

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