Anticorps Recombinant de lapin anti-LAIR1

LAIR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241805G2

N° de cat : 98326-1-PBS

Synonymes

Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, LAIR 1, hLAIR1, CD305

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Galerie de données de validation

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  FC experiment of human PBMCs using 98326-1-RR (same clone as 98326-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.13 ug Anti-Human LAIR1 Rabbit RecAb (98326-1-RR, Clone:241805G2) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD19. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98326-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98326-1-RR (same clone as 98326-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.13 ug Anti-Human LAIR1 Rabbit RecAb (98326-1-RR, Clone:241805G2) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98326-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98326-1-PBS cible LAIR1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: leukocyte-associated immunoglobulin-like receptor 1
• Masse moléculaire calculée: 287 aa, 31 kDa
• Numéro d’acquisition GenBank: BC027899
• Symbole du gène: LAIR1
• Identification du gène (NCBI): 3903
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

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