Anticorps Recombinant de lapin anti-LAIR1

LAIR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Biotin

CloneNo.

241805G2

N° de cat : Biotin-FcA98326

Synonymes

CD305, hLAIR1, LAIR 1, LAIR-1, Leukocyte-associated immunoglobulin-like receptor 1

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Galerie de données de validation

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  FC experiment of human PBMCs using Biotin-FcA98326

  1x10^6 human PBMCs were surface stained with 0.25 ug Biotin Anti-Human LAIR1 Rabbit RecAb (Biotin-FcA98326, Clone: 241805G2) or FcZero-rAb™ Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9), and PE Streptavidin (Cat.No. PF00021). Cells were co-stained with FcZero-rAb™ APC Anti-Human CD19. Cells were not fixed. Lymphocytes were gated.

• 

  FC experiment of human PBMCs using Biotin-FcA98326

  1x10^6 human PBMCs were surface stained with 0.25 ug Biotin Anti-Human LAIR1 Rabbit RecAb (Biotin-FcA98326, Clone: 241805G2) (red) or FcZero-rAb™ Biotin Rabbit IgG Isotype Control Recombinant Antibody (Biotin-FcA98136, Clone: 240953C9) (blue), and PE Streptavidin (Cat.No. PF00021). Cells were not fixed. Lymphocytes were gated.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

Biotin-FcA98326 cible LAIR1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LAIR1 Protéine recombinante Eg2329
• Nom complet: leukocyte-associated immunoglobulin-like receptor 1
• Masse moléculaire calculée: 287 aa, 31 kDa
• Numéro d’acquisition GenBank: BC027899
• Symbole du gène: LAIR1
• Identification du gène (NCBI): 3903
• Conjugaison: Biotin
• Excitation/Emission maxima wavelengths: -
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

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