Anticorps Recombinant de lapin anti-LAIR1

LAIR1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

FITC Plus Fluorescent Dye

CloneNo.

241805G2

N° de cat : FITC-98326

Synonymes

241805G2, CD305, hLAIR1, LAIR 1, LAIR-1

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Galerie de données de validation

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  FC experiment of human PBMCs using FITC-98326

  1x10^6 FC receptor blocked human PBMCs were surface stained with CoraLite® Plus 647 Anti-Human CD19, and 5 ul FITC Plus Anti-Human LAIR1 Rabbit RecAb (FITC-98326, Clone: 241805G2) or FITC Plus Rabbit IgG Isotype Control RecAb (FITC-98136, Clone: 240953C9). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

• 

  FC experiment of human PBMCs using FITC-98326

  1x10^6 FC receptor blocked human PBMCs were surface stained with 5 ul FITC Plus Anti-Human LAIR1 Rabbit RecAb (FITC-98326, Clone: 241805G2) (red) or FITC Plus Rabbit IgG Isotype Control RecAb (FITC-98136, Clone: 240953C9)(blue). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

FITC-98326 cible LAIR1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LAIR1 Protéine recombinante Eg2329
• Nom complet: leukocyte-associated immunoglobulin-like receptor 1
• Masse moléculaire calculée: 287 aa, 31 kDa
• Numéro d’acquisition GenBank: BC027899
• Symbole du gène: LAIR1
• Identification du gène (NCBI): 3903
• Conjugaison: FITC Plus Fluorescent Dye
• Excitation/Emission maxima wavelengths: 495 nm / 524 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

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