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Anticorps Recombinant de lapin anti-LEPR

LEPR Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241692G9

N° de cat : 84464-4-PBS

Synonymes

LEP-R, LEP R, HuB219, DB, CD295

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using LEPR Recombinant antibody (84464-4-RR)

    WB analysis using 84464-4-RR (same clone as 84464-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84464-4-RR (LEPR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84464-4-PBS in a different storage buffer formulation.

Informations sur le produit

84464-4-PBS cible LEPR dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Protéine recombinante
Nom complet leptin receptor
Masse moléculaire calculée 132 kDa
Poids moléculaire observé120 kDa
Numéro d’acquisition GenBankNM_002303
Symbole du gène LEPR
Identification du gène (NCBI) 3953
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction (PMID: 22249808). Leptin acts through the leptin receptor (LEPR, also known as OB-R), a single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, LEPR mediates signaling through JAK2/STAT3 (PMID: 9102398). LEPR plays an important role in the regulation of glucose homeostasis via feeding and adiposity. Alternatively spliced transcript variants encoding different isoforms of LEPR have been described.

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