Anticorps Recombinant de lapin anti-LIFR

LIFR Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250110B11

N° de cat : 85827-2-PBS

Synonymes

CD118, LIF R, LIF receptor, LIF-R, SJS2

---

Galerie de données de validation

• 

  WB analysis using 85827-2-RR (same clone as 85827-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85827-2-RR (LIFR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85827-2-PBS in a different storage buffer formulation.

---

Informations sur le produit

85827-2-PBS cible LIFR dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LIFR Protéine recombinante Eg2599
• Nom complet: leukemia inhibitory factor receptor alpha
• Masse moléculaire calculée: 124 kDa
• Poids moléculaire observé: 190 kDa, 170 kDa
• Numéro d’acquisition GenBank: NM_001127671.1
• Symbole du gène: LIFR
• Identification du gène (NCBI): 3977
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LIFR, also known as CD118, is a subunit of a receptor for leukemia inhibitory factor (LIF). LIF is a pleiotropic cytokine of the interleukin-6 family that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIFR is the low-affinity binding chain that, together with the high-affinity converter subunit gp130, forms a high-affinity receptor complex that mediates the action of LIF. The high-affinity complex also binds a related cytokine, oncostatin M (PMID: 8999038). LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway (PMID: 23001183). LIFR appeared as doublets with 190 and 170 kDa (PMID: 10858440). They represented different glycosylated forms of the LIFR in different steps of protein maturation.

{{ptg:RelatedPrimaryAntibodies}}