Anticorps Recombinant de lapin anti-LIFR

LIFR Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250110B3

N° de cat : 98432-2-PBS

Synonymes

CD118, LIF R, LIF receptor, LIF-R, SJS2

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Galerie de données de validation

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  FC experiment of JAR using 98432-2-RR (same clone as 98432-2-PBS)

  1x10^6 JAR cells were surface stained with 0.25 ug Anti-Human LIFR Rabbit RecAb (98432-2-RR, Clone: 250110B3) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98432-2-PBS in a different storage buffer formulation.

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Informations sur le produit

98432-2-PBS cible LIFR dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LIFR Protéine recombinante Eg2599
• Nom complet: leukemia inhibitory factor receptor alpha
• Masse moléculaire calculée: 124 kDa
• Numéro d’acquisition GenBank: NM_001127671.1
• Symbole du gène: LIFR
• Identification du gène (NCBI): 3977
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

LIFR, also known as CD118, is a subunit of a receptor for leukemia inhibitory factor (LIF). LIF is a pleiotropic cytokine of the interleukin-6 family that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIFR is the low-affinity binding chain that, together with the high-affinity converter subunit gp130, forms a high-affinity receptor complex that mediates the action of LIF. The high-affinity complex also binds a related cytokine, oncostatin M (PMID: 8999038). LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway (PMID: 23001183).

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