Anticorps Polyclonal de lapin anti-LILRB2/CD85d

LILRB2/CD85d Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 14154-1-PBS

Synonymes

LILRB2, CD85 antigen-like family member D, CD85d, ILT 4, ILT4

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Galerie de données de validation

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  WB analysis using 14154-1-AP (same clone as 14154-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 14154-1-AP (LILRB2/CD85d antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14154-1-PBS in a different storage buffer formulation.

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  IF Staining of THP-1 using 14154-1-AP (same clone as 14154-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using LILRB2/CD85d antibody (14154-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 14154-1-PBS in a different storage buffer formulation.

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Informations sur le produit

14154-1-PBS cible LILRB2/CD85d dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LILRB2/CD85d Protéine recombinante Ag5336
• Nom complet: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
• Masse moléculaire calculée: 598 aa, 65 kDa
• Poids moléculaire observé: 60-65 kDa
• Numéro d’acquisition GenBank: BC036827
• Symbole du gène: LILRB2
• Identification du gène (NCBI): 10288
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LILRB2 (Leukocyte immunoglobulin-like receptor subfamily B member 2), also known as ILT4, CD85d or MIR10, is a type I transmembrane glycoprotein that contains four extracellular immunoglobulin domains, a transmembrane domain, and three cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (PMID: 33928233). LILRB2 is mainly expressed in immunocytes including monocytes, macrophages, and dendritic cells, and transduces negative signals by its association with SHP-1 phosphatase via the ITIMs (PMID: 35717259). LILRB2 can interact with various ligands such as HLA-A, HLA-B, HLA-C, HLA-G, HLA-F, CD1c, CD1d, angiopoietin-like proteins (ANGPTLs), and SEMA4A.

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