Anticorps Recombinant de lapin anti-LILRB2/CD85d

LILRB2/CD85d Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250299A6

N° de cat : 98488-3-PBS

Synonymes

LILRB2, CD85 antigen-like family member D, CD85d, ILT 4, ILT4

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Galerie de données de validation

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  FC experiment of human PBMCs using 98488-3-RR (same clone as 98488-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LILRB2/CD85d Rabbit RecAb (98488-3-RR, Clone:250299A6) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98488-3-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98488-3-RR (same clone as 98488-3-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human LILRB2/CD85d Rabbit RecAb (98488-3-RR, Clone: 250299A6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98488-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98488-3-PBS cible LILRB2/CD85d dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LILRB2/CD85d Protéine recombinante Eg2839
• Nom complet: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
• Masse moléculaire calculée: 65 kDa
• Numéro d’acquisition GenBank: NM_005874.4
• Symbole du gène: LILRB2
• Identification du gène (NCBI): 10288
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

LILRB2 (Leukocyte immunoglobulin-like receptor subfamily B member 2), also known as ILT4, CD85d or MIR10, is a type I transmembrane glycoprotein that contains four extracellular immunoglobulin domains, a transmembrane domain, and three cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (PMID: 33928233). LILRB2 is mainly expressed in immunocytes including monocytes, macrophages, and dendritic cells, and transduces negative signals by its association with SHP-1 phosphatase via the ITIMs (PMID: 35717259). LILRB2 can interact with various ligands such as HLA-A, HLA-B, HLA-C, HLA-G, HLA-F, CD1c, CD1d, angiopoietin-like proteins (ANGPTLs), and SEMA4A.

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