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Anticorps Polyclonal de lapin anti-LLGL1

LLGL1 Polyclonal Antibody for WB, IF/ICC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, ELISA

Conjugaison

Non conjugué

N° de cat : 22496-1-PBS

Synonymes

lethal giant larvae homolog 1 (Drosophila), Hugl-1, Hugl1

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using LLGL1 Polyclonal antibody (22496-1-AP)

    WB analysis using 22496-1-AP (same clone as 22496-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 22496-1-AP (LLGL1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22496-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using LLGL1 Polyclonal antibody (22496-1-AP)

    IF Staining of HepG2 using 22496-1-AP (same clone as 22496-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LLGL1 antibody (22496-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 22496-1-PBS in a different storage buffer formulation.

Informations sur le produit

22496-1-PBS cible LLGL1 dans les applications de WB, IF/ICC, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène LLGL1 Protéine recombinante Ag18057
Nom complet lethal giant larvae homolog 1 (Drosophila)
Masse moléculaire calculée 1064 aa, 115 kDa
Poids moléculaire observé115 kDa
Numéro d’acquisition GenBankBC151838
Symbole du gène LLGL1
Identification du gène (NCBI) 3996
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purifié par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Lethal giant larvae (Lgl) is a scaffolding protein that regulates the establishment of apical-basal polarity in epithelial cells. The human homologs of Lgl are known as LLGL1 and LLGL2. LLGL1 is a tumor suppressor in multiple human cancers, including hepatocellular carcinoma, malignant melanoma, and colorectal cancer (PMID: 34178676; 15735678; 16170365). LLGL2 functions as a promoter of tumor growth and not as a tumor suppressor in ER+ breast cancer (PMID: 30996345).

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