Anticorps Polyclonal de lapin anti-LLGL2

LLGL2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15993-1-PBS

Synonymes

LLGL scribble cell polarity complex component 2, Lethal(2) giant larvae protein homolog 2, HGL

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Galerie de données de validation

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  WB analysis using 15993-1-AP (same clone as 15993-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15993-1-AP (LLGL2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15993-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 15993-1-AP (same clone as 15993-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LLGL2 antibody (15993-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 15993-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15993-1-PBS cible LLGL2 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LLGL2 Protéine recombinante Ag8867
• Nom complet: lethal giant larvae homolog 2 (Drosophila)
• Masse moléculaire calculée: 356aa,40 kDa; 1020aa,113 kDa
• Poids moléculaire observé: 113-120 kDa
• Numéro d’acquisition GenBank: BC010879
• Symbole du gène: LLGL2
• Identification du gène (NCBI): 3993
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Lethal giant larvae (Lgl) is a scaffolding protein that regulates the establishment of apical-basal polarity in epithelial cells. The human homologs of Lgl are known as LLGL1 and LLGL2. LLGL1 is a tumor suppressor in multiple human cancers, including hepatocellular carcinoma, malignant melanoma, and colorectal cancer (PMID: 34178676; 15735678; 16170365). LLGL2 functions as a promoter of tumor growth and not as a tumor suppressor in ER+ breast cancer (PMID: 30996345).

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