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Anticorps Polyclonal de lapin anti-LPXN

LPXN Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31231-1-PBS

Synonymes

LDPL, LDLP

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using LPXN Polyclonal antibody (31231-1-AP)

    WB analysis using 31231-1-AP (same clone as 31231-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31231-1-AP (LPXN antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31231-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A549 cells using LPXN Polyclonal antibody (31231-1-AP)

    IF Staining of A549 using 31231-1-AP (same clone as 31231-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using LPXN antibody (31231-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 31231-1-PBS in a different storage buffer formulation.

Informations sur le produit

31231-1-PBS cible LPXN dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène LPXN Protéine recombinante Ag34956
Nom complet leupaxin
Masse moléculaire calculée 43 kDa
Poids moléculaire observé 40-50 kDa
Numéro d’acquisition GenBankBC019035
Symbole du gène LPXN
Identification du gène (NCBI) 9404
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LPXN, also known as Leupaxin, LDPL, belongs to the paxillin family. LPXN Contributes to the regulation of cell adhesion, spreading, and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events (PMID: 20543562). LPXN has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of the focal adhesion kinase family (PMID: 9565592). Studies in breast cancer implicate LPXN is involved in the regulation of ER action as a co-factor (PMID: 25955236). LPXN is expressed in prostate cancer cells and its expression intensity is directly linked to PCa progression (PMID: 18451096).

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