Anticorps Recombinant de lapin anti-LRP1

LRP1 Recombinant Antibody for FC

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

5A6

N° de cat : 65594-1-PBS

Synonymes

5A6, A2MR, Alpha 2 macroglobulin receptor, Alpha-2-macroglobulin receptor, APOER

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Galerie de données de validation

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  FC experiment of U-87 MG using 65594-1-MR (same clone as 65594-1-PBS)

  1x10^6 U-87 MG cells were surface stained with 0.25 ug Anti-Human LRP1 (5A6) Mouse IgG2a RecAb (65594-1-MR, Clone: 5A6) (red) or Mouse IgG2a Isotype Control (C1.18.4) (65208-1-Ig, Clone: C1.18.4) (blue), and PE-conjugated Goat Anti-Mouse IgG. Cells were not fixed. This data was developed using the same antibody clone with 65594-1-PBS in a different storage buffer formulation.

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Informations sur le produit

65594-1-PBS cible LRP1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Full length native protein (purified)
• Nom complet: low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
• Masse moléculaire calculée: 505 kDa
• Numéro d’acquisition GenBank: BC045107
• Symbole du gène: LRP1
• Identification du gène (NCBI): 4035
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

LRP1 (Prolow-density lipoprotein receptor-related protein 1), also known as A2MR, APOER and CD91, is a type I transmembrane protein that belongs to the LDLR family. LRP1 is synthesized as a transmembrane glycosylated precursor of 600 kDa, and is subsequently cleaved to generate a large 515-kDa N-terminal extracellular subunit and an 85-kDa C-terminal transmembrane subunit, which are noncovalently associated with one another (PMID: 2112085; 8546712). LRP1 is a multifunctional receptor involved in the clearance of a large number of diverse ligands and modulating various cellular processes. LRP1 is implicated in conditions such as atherosclerosis, cancer and neurodegenerative diseases (PMID: 28381441).

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