Anticorps Polyclonal de lapin anti-LRP4

LRP4 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24434-1-PBS

Synonymes

MEGF7, LRP-4, LRP10, LRP 4, Low-density lipoprotein receptor-related protein 4

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Galerie de données de validation

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  WB analysis using 24434-1-AP (same clone as 24434-1-PBS)

  Mouse brain tissue was subjected to SDS PAGE followed by western blot with 24434-1-AP (LRP4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24434-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24434-1-PBS cible LRP4 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LRP4 Protéine recombinante Ag19487
• Nom complet: low density lipoprotein receptor-related protein 4
• Masse moléculaire calculée: 1905 aa, 212 kDa
• Poids moléculaire observé: 240 kDa
• Numéro d’acquisition GenBank: BC136667
• Symbole du gène: LRP4
• Identification du gène (NCBI): 4038
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).

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