Anticorps Recombinant de lapin anti-LRP4

LRP4 Recombinant Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242157D11

N° de cat : 84973-1-PBS

Synonymes

242157D11, KIAA0816, Low-density lipoprotein receptor-related protein 4, LRP 4, LRP10

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Galerie de données de validation

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  WB analysis using 84973-1-RR (same clone as 84973-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84973-1-RR (LRP4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

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  IF Staining of PC-12 using 84973-1-RR (same clone as 84973-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed PC-12 cells using LRP4 antibody (84973-1-RR, Clone: 242157D11 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84973-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84973-1-RR against Human LRP4 were performed. The affinity constant is 70.0 nM.

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Informations sur le produit

84973-1-PBS cible LRP4 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LRP4 Protéine recombinante Ag19413
• Nom complet: low density lipoprotein receptor-related protein 4
• Masse moléculaire calculée: 1905 aa, 212 kDa
• Poids moléculaire observé: 245 kDa
• Numéro d’acquisition GenBank: BC136667
• Symbole du gène: LRP4
• Identification du gène (NCBI): 4038
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).

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