Anticorps Polyclonal de lapin anti-LRRC8A/SWELL1

LRRC8A/SWELL1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 17155-1-PBS

Synonymes

LRRC8A, SWELL1, LRRC8, Leucine-rich repeat-containing protein 8A, KIAA1437

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Galerie de données de validation

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  WB analysis using 17155-1-AP (same clone as 17155-1-PBS)

  rat lung tissue were subjected to SDS PAGE followed by western blot with 17155-1-AP (LRRC8A/SWELL1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse brain using 17155-1-AP (same clone as 17155-1-PBS)

  IP result of anti-LRRC8A/SWELL1 (IP:17155-1-AP, 4ug; Detection:17155-1-AP 1:800) with mouse brain tissue lysate 2100 ug. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 17155-1-AP (same clone as 17155-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 17155-1-AP (LRRC8A/SWELL1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 17155-1-AP (same clone as 17155-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 17155-1-AP (LRRC8A/SWELL1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

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Informations sur le produit

17155-1-PBS cible LRRC8A/SWELL1 dans les applications de WB, IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LRRC8A/SWELL1 Protéine recombinante Ag10062
• Nom complet: leucine rich repeat containing 8 family, member A
• Masse moléculaire calculée: 810 aa, 94 kDa
• Poids moléculaire observé: 94 kDa
• Numéro d’acquisition GenBank: BC051322
• Symbole du gène: LRRC8A
• Identification du gène (NCBI): 56262
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LRRC8A, also named as SWELL1, KIAA1437 and LRRC8, belongs to the LRRC8 family. LRRC8A is a ubiquitous and integral component of the VRAC and has been reported to be required for regulation of cell volume. It indicates that LRRC8A plays a role in regulating the flow of ions, especially anions, into and out of cells (PMID: 32079488). Additionally, there have been several reports that LRRC8A is critical for differentiation of adipocytes and lymphocytes (PMID: 31323188). The molecular weight of LRRC8A is 94 kDa.

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