Anticorps Monoclonal anti-LRRC8C

LRRC8C Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

4A6A4

N° de cat : 68323-1-PBS

Synonymes

AD158, DKFZp586J1119, FAD158, LRRC8C

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Galerie de données de validation

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  WB analysis of U2OS using 68323-1-Ig (same clone as 68323-1-PBS)

  U2OS cells were subjected to SDS PAGE followed by western blot with 68323-1-Ig (LRRC8C antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

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  WB analysis using 68323-1-Ig (same clone as 68323-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68323-1-Ig (LRRC8C antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 68323-1-Ig (same clone as 68323-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LRRC8C antibody (68323-1-Ig, Clone: 4A6A4 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

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Informations sur le produit

68323-1-PBS cible LRRC8C dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: LRRC8C Protéine recombinante Ag17001
• Nom complet: leucine rich repeat containing 8 family, member C
• Masse moléculaire calculée: 803 aa, 92 kDa
• Poids moléculaire observé: 105 kDa
• Numéro d’acquisition GenBank: BC113973
• Symbole du gène: LRRC8C
• Identification du gène (NCBI): 84230
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LRRC8C (Leucine-rich repeat-containing protein 8C), also known as AD158, is a non-essential component of the volume-regulated anion channel (VRAC, also known as VSOAC channel), which is required to maintain a constant cell volume in response to extracellular or intracellular permeability changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PMID:24790029; 26824658; 28193731).

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