Anticorps Polyclonal de lapin anti-LSR

LSR Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18216-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of HT-29 using 18216-1-AP (same clone as 18216-1-PBS)

  HT-29 cells (LSR+) and HeLa cells (LSR-) were subjected to SDS PAGE followed by western blot with 18216-1-AP (LSR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  WB analysis using 18216-1-AP (same clone as 18216-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18216-1-AP (LSR antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse stomach using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse stomach tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse stomach using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse stomach tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse liver using 18216-1-AP (same clone as 18216-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 18216-1-AP (LSR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18216-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18216-1-PBS cible LSR dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LSR Protéine recombinante Ag12961
• Nom complet: lipolysis stimulated lipoprotein receptor
• Masse moléculaire calculée: 71 kDa
• Poids moléculaire observé: 60-70 kDa, 56 kDa
• Numéro d’acquisition GenBank: BC004381
• Symbole du gène: LSR
• Identification du gène (NCBI): 51599
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LSR (lipolysis stimulated lipoprotein receptor) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids (PMID: 10224102). This remnant receptor binds both apoB- and apoE-containing lipoproteins and displays greatest affinity for TG-rich lipoproteins. Distribution of LSR causes embryonic lethality in mice, indicating that the expression of LSR is critical for liver and embryonic development (PMID: 15265030). Investigations show that LSR is a multimer consisting of α subunit (68 kDa) and β subunit (56 kDa) associated through disulfide bridges (PMID: 10224102; 19188430; 18644789).

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