Anticorps Recombinant de lapin anti-LTBP2

LTBP2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241911C7

N° de cat : 84574-4-PBS

Synonymes

LTBP3, C14orf141, 241911C7, LTBP-2, LTBP 2

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Galerie de données de validation

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  WB analysis using 84574-4-RR (same clone as 84574-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84574-4-RR (LTBP2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84574-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84574-4-RR

  Biolayer interferometry (BLl) kinetic assays of 84574-4-RR against Human LTBP2 were performed. The affinity constant is 0.779 nM.

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Informations sur le produit

84574-4-PBS cible LTBP2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: LTBP2 Protéine recombinante Ag29720
• Nom complet: latent transforming growth factor beta binding protein 2
• Masse moléculaire calculée: 1821 aa, 195 kDa
• Poids moléculaire observé: 290 kDa
• Numéro d’acquisition GenBank: BC078659
• Symbole du gène: LTBP2
• Identification du gène (NCBI): 4053
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LTBP2, an extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-β binding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma (PMID: 20179738 ) . LTBP2 is a biomarker of heart failure. LTBP2 has a molecular weight of 260 kDa (PMID: 20878956), and even larger molecular weights of 290 and 310 kDa were detected in tissue extracts. (PMID: 8524260)

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