Anticorps Polyclonal de lapin anti-LUC7L2

• Phare
• Validé par KD/KO

LUC7L2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24202-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of K-562 using 24202-1-AP (same clone as 24202-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

  WB result of LUC7L2 antibody (24202-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LUC7L2 transfected HeLa cells. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

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  IF Staining of A431 using 24202-1-AP (same clone as 24202-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed A431 cells using LUC7L2 antibody (24202-1-AP) at dilution of 1:600 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24202-1-PBS cible LUC7L2 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LUC7L2 Protéine recombinante Ag21135
• Nom complet: LUC7-like 2 (S. cerevisiae)
• Masse moléculaire calculée: 392 aa, 47 kDa
• Poids moléculaire observé: 46 kDa
• Numéro d’acquisition GenBank: BC017163
• Symbole du gène: LUC7L2
• Identification du gène (NCBI): 51631
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purifié par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RNA-binding protein LUC7L2 as a negative regulator of DNA virus-triggered innate immune response. Mechanistically, LUC7L2 directly bound to intron 3 of MITA precursor messenger RNA, inhibited its splicing, and promoted its nonsense-mediated decay, leading to its downregulation at the protein level (PMID:34155193). Moreover, LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing (PMID:33961773).

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