Anticorps Polyclonal de lapin anti-LYPD6B

LYPD6B Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 25508-1-PBS

Synonymes

CT116, Ly6/PLAUR domain-containing protein 6B, LYPD7

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Galerie de données de validation

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  IHC staining of mouse lung using 25508-1-AP (same clone as 25508-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 25508-1-AP (LYPD6B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25508-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse lung using 25508-1-AP (same clone as 25508-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 25508-1-AP (LYPD6B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25508-1-PBS in a different storage buffer formulation.

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Informations sur le produit

25508-1-PBS cible LYPD6B dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: LYPD6B Protéine recombinante Ag22008
• Nom complet: LY6/PLAUR domain containing 6B
• Masse moléculaire calculée: 183 aa, 20 kDa
• Numéro d’acquisition GenBank: BC040176
• Symbole du gène: LYPD6B
• Identification du gène (NCBI): 130576
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

LYPD6B (containing the Ly6/PLAUR domain protein 6B), also known as LYPD7, is a member of the Ly6/uPAR superfamily of proteins. These proteins typically exhibit membrane-anchoring properties and participate in critical cellular signaling and adhesion processes. It is predominantly expressed in the central nervous system. LYPD6B functions as a key regulatory subunit that interacts with and modulates nicotinic acetylcholine receptors (nAChRs), specifically influencing their maturation, stability, and functional properties at synapses. This interaction is crucial for normal cholinergic signaling, which underpins cognitive functions such as learning and memory. Dysfunction of the LYPD6B is associated with multiple neurological disorders. (PMID: 23186997, PMID: 34631692, PMID: 39433742)

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